Fine, fair enough. If fixing TeX is hopeless, then so be it. I assumed it just needed a few small tweaks, maybe combined with slightly cleverer PDF viewers. Guess I was wrong.
But then what should people use for math? I suppose there's MathJax, which seems to have put some thought into accessibility.
There's still a problem though. I can't help but notice that the journal you linked to is a biology journal. In some math/CS circles which are TeX's "home turf", TeX is far more entrenched to the point where I'm not sure such things even exist. For instance, arxiv sort of supports HTML, but not really:
https://arxiv.org/help/submit_html
So there I guess step 1 is to make HTML a viable option.