You mean more or less severe than long-term negative effects of sugar or alchocol? And there is greater stigma for non-drinkers than for drinkers in our societies so go figure...
i am guessing this is already the case in certain subcultures but I think there is a chance it could reach the mainstream in blue coastal cities.
As a relatively boring person, mucking about with the body chemistry is not preferred.
If the doctor says so, OK.