Upstate suffers from high taxes and regulations introduced by the Governor with NYC in mind. Combine that with long winters and urban decay and we see that many bright young professionals born here end up fleeing once their parents retire.
I personally am planning on moving to Raleigh, NC in a few years. I only rent an apartment now so I'm mostly insulated from the astronomical property and school taxes, but I feel the state as a whole does not have my best interests in mind.