I live in a pretty quite neighborhood in a suburb of Chicago and I see Amazon Prime vans drive by all the time. The driver parks, hops out, runs around to grab the package, drops it off, drives on, and repeat.
This is a great scenario where you don't need total autonomy all the time: the delivery person could drive the highways and complicated parts, and then when there's a cluster of deliveries where the speed limit is 25mph and the roads are clear and regular, the van could go from house to house, with the delivery person hanging out in back or something.
It's not full self-driving, but it seems like it could make deliveries a little more efficient.