OpenResty is pretty great, I think people would abuse the heck out of it it weren't so heavily Lua but when people do find it they build some amazing stuff (like Kong).
We have a fair number of people running OpenResty on Fly.io. It's a pretty good fit. I'd _love_ to have an OpenResty based on v8/JavaScript that wasn't so heavily tied to nginx events, I could build so many neat apps.