One thing I haven't heard much about is the packaging of wasm runtimes. For example, instead of including all of the .net runtime as scripts that need to be downloaded, we could have canonical releases of major libraries pre-installed in our browsers, and could even have the browser have pre-warmed runtimes ready to execute, in theory. So if we wanted to have a really fast startup time for .net, my browser could transparently cache a runtime. Basically like CDN references to JS files, but for entire language runtimes.
This would obviate the need for browsers to natively support language runtimes. It's conceptually a way to get back to something like Flash or SilverLight but with a super simple fallback that doesn't require any plugin to be installed.