1 — Sure. But Nix isn't exactly the most friendly package manager to begin with. I wouldn't recommend it if you're not comfortable creating volumes.
2 — Could you explain? Mine is on and working, I didn't need to do anything else.
3 — Is this if you have login items that need nix to be available? I don't have this so I haven't noticed.
4 — I've never run into this, but again I might just not use Nix for the kind of things that would cause issues.