Calculate, how many lives are already saved and will be saved in future by nuclear reactors in comparison to other sources of energy. Calculate how many lives will be lost in worstests scenarios. Multiple number by probability and sum up.
For example:
* nuclear reactor can save 1000 lives per year in 100 years of it life with 0.9999 probability;
* in worstest case, with 0.0001 probability, it can kill 10000 humans per year in 1000 years.
Result: 1000⋅100⋅0,9999 + −10000⋅1000⋅0,0001 = 98,99E3
0,0001 probability is too optimistic - we already have Chernobyl and few other smaller nuclear disasters while number of nuclear stations is much smaller than 1K.