It certainly depends on seniority and experience, the more you have the easier it is to work on your own. You don't need much guidance anymore and you know what communication and planning is needed in advance, so you can do it in batches.
Even for whiteboard discussions, you can buy a literal whiteboard for your work area, hold the meeting over video call, and exchange photos afterward. It's not quite as low friction as walking up to a whiteboard in the office with a coworker, but, at least you know the damn markers will work.
Maintaining WLB is something one needs to be attentive to. Having a dedicated work area as well as maintaining specific work hours (and sticking to them) are key. Other than that, I don't think maintaining WLB at home has to be any tougher than at the office. Kids present special issues, but, if you're a non-WFHer, you already have provisions for the kids during work hours, anyway.
But for a lot of white collar professionals at an associate to mid senior level, there's plenty of work that you should be able to do independently.