I think a lot of people miss the point of Guile Emacs. Making Emacs faster or having access to all of Guile's features and libraries is not what the project intends - they are just possible free perks. The purpose of Guile was to allow any project to be extensible like Emacs with an independent module. That means instead of the Emacs folk implementing a native compiler just for themselves, some GNU project that uses Lua to rewrite existing Emacs Lisp libraries, or awesome small projects like Lilypond or Gnucash to have to deal with Guile Scheme all by themselves, all these projects can pool resources and improve their performance and features together. Guile Emacs is not about Emacs, it's about bringing more unity across all the islands of GNU projects.
If I had the know how / the time I would be less talk.