That seems like one of those things that by their nature are extremely unlikely to come about, seeing as to have a decent "win" condition you'd have to be able to understand what makes a winning business in real life.
Either no one wants to out their trade secret sauce; or there really isn't anyone that knows how.
Now I bet you could maybe stealth it by pitching a business "failure" simulator. Even then Though you may run into the same issues.
I'd also play the hell out of it. No MBA, but I absolutely love unintuitive optimization problems, and playing with hypotheticals.
I just have the feeling that if we knew enough to convincingly gamify it, it may not necessarily be a game worth playing when you could be doing the real thing instead.
I'm laughing at the mental image of contests wherein people bring their pet company in for evaluation for entry into a business program or something.