TO address some of your points;
poor ecosystem of libraries: many great libraries, some incomplete. you must not be afraid to look at the source code to understand and edit
poor community coordination: true, there are few large scale community lisp projects. be the change you want to see
dependency limitations with quicklisp: like what? quicklisp works great. if you are talking about loading several versions of the same library at the same time in a single image, this is being researched and developed
poor support for json: no, there is good support
have to restart the server every 20 days: not familiar, I have had lisp servers running for years now
hack to tune GC: no
if I had to redo my project would I choose Lisp? I would choose lisp, yes. there is no more powerful language than this, and believe me, I have tried many