There you go. It's the tyranny of averages: when variation between humans is greater than the effect of the intervention.
This reminds me of reading The How of Happiness and learning that happiness is basically 50% genetics, 10% circumstances and 40% behavior. The author frames that 40% as a really big number, but I thought about it the other way around: if you're unlucky enough to be born into the bottom decile of genetic happiness, then you could do everything right and still be less happy than someone with really good happiness genes who does everything wrong.
Some people get smashed by any lack of sleep, and some people (most notably short sleepers) are totally fine with as little as 4 hours a night. There is no advice that works for both kinds, and formulating advice based on averages is committing a grave fallacy.
I suppose the world of health research is plagued by this erroneous assumption that humans are more or less the same. In some ways sure, but in many ways we are profoundly different.