Instead of TypeScript which is very far from being all-typed, I hope there will be wider adoption for proper Web languages like ReasonML[1], BuckleScript[2], PureScript[3], Elm[4], etc. With a better WebAssembly adoption and once they solve the garbage collection problem[5] and direct DOM access[6] there will no even need in JavaScript "glue".
[1] https://reasonml.github.io/
[2] https://bucklescript.github.io/
[3] https://www.purescript.org/
[5] https://github.com/WebAssembly/gc/issues/44#issuecomment-623...
[6] https://stackoverflow.com/questions/42628328/wasm-access-dom