My wife always worked from home.

But now, she works from home and then can't socialize after hours, except virtually. She can't go anywhere or do anything. Shopping is the only time she gets out, but she didn't like it before and now it's even more stressful.

The difference (unless you have kids or a noisy house) isn't the home bit, it's the not-home bit. For people who aren't introverts, this is a very, very tough time. Their basic needs aren't being met.

I'm lucky that I'm an introvert. This has been a pretty good experience for me. I have no commute, I get more done in the same 8 hours, and all my socializing can be done in my own home. I miss going places a tiny bit, but only the places that have things I can't do at home. (I'm talking Disney World here.)