There is no evidence that his wife provided any of the "mathematical muscle needed for GR", nor is there reason to suspect that she would have been in a position to do so, since she was not a mathematician and had failed the undergraduate physics degree at the institute where she met Einstein (Einstein himself barely passed though).
I'm not sure how much credence I'd put in such an assertion given that Einstein himself wrote in a letter to Mileva:
> “When I read Helmholtz for the first time, it seemed so odd that you were not at my side and today, this is not getting better. I find the work we do together very good, healing and also easier.”
Emphasis added by me.
Having not read the book, Isaacson might have some additional evidence and insights I'm not aware of, but who knows?
Note that this was written when they were both undergraduate students and would study together.