Eh. I think it's a risky gamble.
It does depend on the context. If it was asked in the context of a casual conversation, say in between sessions -- it's ok.
But when I, the interviewer, am asking "do you have any questions for me?" during an interview, I invariably mean it in a professional context. Answering with "what did you have for lunch?" seems to cross the professionalism line somewhat (why the hell do you need to know what I ate?), and may not be appreciated by many. I wouldn't go as far as to outright dismiss the candidate's viability, but for me personally, it's comes across as weird and non-self-aware rather than funny.
(also, as someone who watches a lot of stand-up, I also have a high threshold for humor -- I'm kinda of a humor snob. I like light-heartedness, but contrived failed attempts at humor are grating to me because they often indicate someone's trying too hard. There's an inauthenticity there that rubs me the wrong way.)
So even if you're right, the trouble is an interviewee might not be able to tell a priori if they got someone like you or someone like me. So it's risky.
(otoh, "what are some good lunch spots around here, in your opinion?", mentioned by another commenter, is almost always positive and indicates a candidate's interest in the workplace environment)