tl;dr : you can either keep struggling with the unknown, keep making science, keep searching for the truth to fill the gaps and tame the uncertainty or just choose to believe in some sort of intelligent transcendental designer and sleep happy at night thinking you're special.

I, for one, still choose science. I'd rather have uncertainty till the day I die -knowing that I did my best to make it less so- than giving in to the God of The Gaps.