Tech like Blazor and related asm.js type thinking will eventually replace JS when it bypasses asmjs completely and ships bytecode that the browser executes directly.
I doubt these frameworks will be much different compared to what we are doing today, because we will still need to deal with layouts, alignments, the color and shape and proportion of things, event handlers etc. The usual stuff.
Ragging on React, Vue, Angular is misguided. These frameworks allow developers to write front-ends as if they are applications, because in a lot of cases, this is what the modern "website" really is. They are training the next generation of front-end developers much like how jQuery did in mid 2000s.