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The Baltimore region actually is a hub for gaming companies: MicroProse, Firaxis, Big Huge Games, etc. I'm not overly familiar with the video game industry, but Baltimore/Maryland is no slouch. Zynga has an office in Timonium now (suburbs of Baltimore) where they are hiring.

Bethesda Software too.

For me, this may be more than just a high tech hub. Silicon Valley is great, but in a sense, the balance is tipped too far towards tech. Due to East Coast demographics, geography, and culture, I'm hoping/expecting that East Coast incubators will be a bit more diverse.

I don't want us to be a city that tries to be something it's not. We shouldn't even try to replicate what you have out there, but, I think it's a very creative place where it is possible to do great things with technology, especially if you want to avoid any possible "echo chamber" effects, and especially if you want to bootstrap or do things your own way.