Good question. It's early days, so there's still a lot of work to be done around geo-replication/geo-aware. It depends on the specific use case, but there are a few approaches you could take. You could run a Liftbridge and NATS cluster in each DC with the NATS cluster connected to a global NATS supercluster. Alternatively, you could just run separate Liftbridge clusters and do replication between them (sort of like the MirrorMaker approach in Kafka, though the tooling here is still lacking for Liftbridge).

Longer term, I'd like to take advantage of the recent work in NATS around superclusters and geo-aware subscribers to provide better geo-replication primitives directly inside Liftbridge (https://www.slideshare.net/nats_io/deploy-secure-and-scalabl...).