I wish there was a clean, sharp division between people trying to sell you stuff on the open internet and entities that you are logged in to and already doing business with, such that the latter were guaranteed to be accessible even with maximum blocking.
Exploiting customers is something that needs to be regulated more.
I can only count a handful of sites that break with conventional blockers (uMatrix might be a different story) and those sites I can just avoid doing business with (only one I can remember recently is Patreon where the Facebook/Google ad scripts cause the entire page to be unusable).
Funnily enough, Patreon works without a problem after allowing 2 CDNs and their usercontent domain.
It's painful, but it's (for me) the only sane way to browse. I'm willing to trade a few seconds of determining what 3rd party sources I'm going to allow when visiting a new site in exchange for minimizing tracking and malicious ads.
I've installed them for a couple of friends and family who complained about ads and slow websites, but hadn't known about blockers.
Whenever I turn off my adblockers and visit common sites, it feels like I've been wearing hearing protection in a loud place and I'm now taking them off.
I think it depends on the Inbox type you use as well (e.g. Priority, Default etc...)