Vaccines, on the other hand, especially experimental ones, have been historically known to suffer from contamination (biological or otherwise), and result in strange, hard-to-diagnose problems. These problems are suffered by a tiny population (the experimental group), with no broad societal, medical, or research support -- which makes sense, since the highest societal priority is typically to help as many people as possible. The three main concerns with the vaccines themselves are that (a) there's no biological pressure to attenuate negative effects, (b) the biologic components themselves may infect the patient, without any point of comparison commensurate with widespread viruses in the field, and (c) the other ingredients (stabilizers, preservatives, etc.) in vaccines are often toxic in their own right. In the past it has taken many years, even a decade or more, to get it all right.