lol... if you care about optimizing, you should care about all possible optimizations... (even if most of today's platforms don't)
Other random example: in some edge cases, integer division replacement by a multiplication can still be relevant today (depends on if its a constant, the compiler, and if nothing optimized also on the exact processor, though, because last models are already ultra-fast with the real integer divide instructions), but I suspect in 15 years (maybe even 10) this will be completely irrelevant, at least for high perf targets.