I wonder if anyone's ever heard from SNAP-10. It was the first fission reactor in orbit (1965). It had, uh, problems and was shut down after 43 days. In late November 1979 it had a 'anomalous event', and it had 6 more in the next 6 years... releasing '50 trackable pieces'.
[0] https://web.archive.org/web/20170503083646/https://ston.jsc....