Ok, fleshing that out via google:
"The connection between AZs is expected to typically achieve low single-digit millisecond latency between them on average."
https://knowledgebase.progress.com/articles/Article/expected...
and
1 light-millisecond = 299792.458 meters, so nearly 300 km / 186 miles.
https://www.translatorscafe.com/unit-converter/en-US/length/...
So in 2 milliseconds, light travels 599km or 372 miles.
That's a _hard_ limit. IIRC, modern communications is at a fraction of lightspeed, which would lower it.
There's no reason _not_ to have the AZs for a region in the same metro area, so separated by 10s of km, tops.
10km = 0.0333 light-milliseconds.