"Talking throughout their set" is just rude, that's not even heckling, which I don't support/appreciate, but is considered "part of the experience" by some. "Crowd work" however is a very normal part of lots of stand up acts. I could imagine comedians wanting some way to do that in a digital setting and I suspect that's what is being referred to here.
If anyone haven't seen it done or don't know what I'm talking about Todd Barry has a whole special where it's all he does - appropriately titled "Crowd Work"! :-)