IT for the Blind. (non-profit) Basically like Kickstarter, but applicants will be asking for (pooled) funding for always-too-expensive technology that helps overcome vision problems. Check out Humanware.com for example of this kind of gear.
The main problem with this kind of technology is that it remains very expensive, even as tech in general keeps getting cheaper. A CCTV that would help Grandma write checks and read Christmas cards may cost $1500 on the low end. The market-dominant screen reader applications have been around $800 since I was an accessibility program manager in the 90s. The main problem is that with such a small market they don't get good economies of scale. Some have estimated that we may currently reach as little as 5% of the affected population, and cost is a big factor.
Fundraising for Guide Dogs for the Blind, and their many clones, is ridiculously easy. It's a pitch everyone can understand. Well, guide dogs get many blind people outside their house, but technology lets them keep middle-class jobs, interact with the world via the internet, etc. In terms of fundraising, it's a fairly powerful pitch, but there is no equivalent central non-profit that just focuses on IT. Most of the non-profits out there focus on skills training or fighting the causes of blindness. IT for the Blind will first determine whether applicants can get funding from schools and employers (as required by law), then pass on the many requests that aren't addressed by existing sources.
I've got board members / founders and a UI spec, but haven't been focusing on this one because my consulting work has been keeping me busy. I'll be able to work on it full time in the summer, and having a MVP would make initial donor fundraising much easier.
By the way, you should assume that donated work would be tax deductible, if we get 501(c)(3) status this year. :)
Thanks!