Nitric oxide inhibits the replication cycle of SARS coronavirus (2004)

No idea. Just saw it referenced in media

OK, where does it say black tea increases NO in vivo? I did look at your paper saying black tea inhibits sars, but where actually does it say extracts of it do other than in vitro? (I bet bleach does even better but that doesn't help in reality except for wiping down surfaces).

Reference for beets being linked to NO isn't given. Wiki says "eNOS synthesizes NO from the terminal guanidine-nitrogen of L-arginine and oxygen and yields citrulline as a byproduct", how does that link to beets?

Thanks

Or you could just provide your credentials. Hi my name is XXXX, and I'm certified _______. Here's why I believe NO could be a useful thing to study in the fight against the coronavirus. Otherwise, you're just some random person on the internet contributing to the FUD.

I think you’ve posted enough on a sensitive health topic in a difficult time that you should either post credentials, not comment so frequently as if an authority, or end your comments either saying you are or are not a doctor. It’s to a point where I think admins should nuke these threads. I’m an MD anesthesiologist at an academic center where we have been trialing NO for about a month on these patients - see that wasn’t that hard.

Edit: and just to add, credentials are to make the audience aware of the context and bias of the presenter, not to validate them. A virologist, biochemist, infectious disease specialist, nutritionist, epidemiologist, public health employee, and undergrad aspiring biology major have different perspectives and understanding of the domains involved. Witholding that context (with hostility) should always be suspect.

Thank you for your reply.

So my general impression is that red blood cells are failing to get adequate oxygen, even in cases where the lungs aren't, per se, filled up with fluid to interfere with oxygenation of the blood. I saw a comment somewhere, and I can't find it at the moment, comparing this to altitude sickness, which is a thing I have read up on and which makes some sense to me in terms of my impression of the pathology here.

So what specific pathway would inhibit uptake of oxygen, even in the absence of pneumonia? Typically, that's a side effect of anemia, which can be caused by either lack of B vitamins or lack of iron (which I understand to be also called Heme -- correct me if I'm wrong as I am a lay person here, not a medical professional).

So I'm trying to envision a specific chemical process that disrupts uptake of oxygen or binding of oxygen to the red blood cell and which is not anemia.

This sounds an awful lot like how carbon monoxide poisoning works. So maybe that's a mechanism to look at. The body can be fooled, either by viruses or chemicals of various sorts, to lock up those pathways with things that interfere with what we need.

This is, as I understand it, how Zithromax causes magnesium deficiency: The drug binds to the same receptors as magnesium, so they compete for uptake in the body. You cannot successfully take them together. Taking them together both makes the antibiotic less effective (it should be taken, in fact, with something acid, not something alkaline) and it also prevents the body from adequately absorbing the magnesium.

In practice, the way around this is to time your use of Zithromax and magnesium so that uptake occurs at different hours of the day and they don't compete. This is possible because of the relatively long half life of Zithromax, which means you don't need frequent dosing.

So this is the kind of mental model I'm trying to wrap my mind around. I know some of these types of antagonistic processes exist and if we can figure out what the mechanism is here for how people are basically suffocating, it should cast light on a solution.

Absolutely, but it can be difficult for non-specialists to tell them apart.

The anti-5G nonsense is spread with a similar anti-government spin to the original post by Alex3917.

The herbal tea market includes everything from making your own ginger tea, to a box costing $20 and promoting some idea of ancient Indian spiritualism and vitality.

It is a mistake. One that is made by both proponents and opponents of non-mainstream medicine.

I was going to ask what country with mainstream medicine has no profit motive, but then I saw your strawman where you equate herbal tea with chopping down phone masts.

Word of advice - pull your head out yer arse.

No, and not especially in the current situation.

It’s far too convenient to have a distilled source of nutrients/flavor as opposed to shopping, cleaning, preparing it and then storing it such that it is available without a lot of thought/planning.

Of course, this is not a general statement, it only applies to some stuff. I enjoy “regular” food too much for that!

Yes, they do that. It would be consistent with the results seen:

Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust https://www.medrxiv.org/content/10.1101/2020.04.07.20056788v...

From what I understand, this is important for people who show (severe) symptoms of Covid-19, not as a preventive drug. So no reason to take it until clear symptoms show up.

>But seriously, it can't be good to walk around with a boner all day every day. Could be intimidating for women too. And embarrassing for men. Maybe if it's effective to people already infected and in hospital anyway. But I couldn't see this socially feasible as a preventative drug.

That's not how viagra works. It makes an erection possible, it doesn't cause one.

it inhibits an enzyme responsible for constricting bloodflow, as far as I know.

the whole viagra causes boners thing is really just a convenient gimmick for comedians.

if you want something that causes a boner, look at percutaneous perineal electrostimulation[0].

when THAT becomes the treatment for covid19 we're in trouble.

[0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435023/

thanks, I always get those mixed up. Its most frustrating