If you do it, do you lose the ability to annotate?

I also use reMarkable as a (pretty good) EPUB reader, but it is really slow when opening the book for the first time or changing the rendering settings (font size, margins, etc.).

It can sometimes take a minute or two and sometimes it just hangs completely and you have to close the book and re-open it. I assume it's because it has to somehow render the whole book, to support the handwritten annotations and put them in correct places.