Assuming, on the off chance, that this isn't some sort of quack treatment ploy, anything that works significantly would be a plus.

I'm on my 13th antidepressant now that is yet-again not working well and I'm starting to wonder if my condition is inflammation-mediated rather than receptor- or neurotransmitter-caused as only mirtazapine (also a powerful antihistamine) ever helped me significantly, but only for a limited time.