As of now, Bootstrap 5 cannot be considered for use in any website with heavy use from enterprise users.
Edit: though it is nice to see that Chromium Edge is already catching up to Spartan Edge!
It has gotten to the point where IE11 in a VM is my main browser for testing and debugging.
It's another story if you are selling, but if the users must use your application, they will click on the other blue e icon.
https://i.postimg.cc/FzBj9Ttp/Screenshot-20200407-084447.png
In practice we find solutions, such as installing chrome or using mobile devices. I know it depends on the domain and the country, but companies with outdated desktop pc running only internet explorer are becoming rare. We prefer to refuse one of them than wasting time supporting outdated environments.
I'm more receptive to backwards compatibility concerns than some in the thread. But when IT admins have new software available, disable and block it arbitrarily, and then complain that new services aren't supported by the old software, I lose my patience.
The only reason anybody has ever given me for disabling Edge is that users find it confusing. If you haven't educated your users on Edge and feel that they are only appropriately trained for IE for the past 5 years, you're not really trying to roll forward with the industry and you're going to be left behind due to your own stupidity. No sympathy.
We gotta move forward. The web can't be held hostage over decade old corporate contracts.