A past client of mine was using one of these relatively obscure frameworks. It's fine when it works (though I feel like the developer experience is much worse than let's say Django REST Framework) but when it breaks good luck figuring it out.

My recommendation is to just go with Django until the performance becomes a problem and it can't be solved by a "boring" solution such as throwing more hardware at it. Even after that, you can still squeeze out extra performance by using Serpy serialisers instead of the built-in DRF ones. Finally, if performance is still a problem then you could potentially use one of these frameworks. In most cases though, your underlying data store will be the bottleneck.

In my client's case, we were looking at a couple requests per second maximum, so they unnecessarily spent extra time learning and using an obscure framework without actually benefiting from it in any way.