Ya, I did a ride along with the highway patrol once. 1 hour of that shift was driving to the far end of our coverage area and waiting for another car. Then blazing down the freeway in the opposite direction at 3am at top speed on what they call a "blood run" (organ in a cooler in the trunk). There are no commercial flights at this time of day and the organ was moving about 5 hours by car. This would have been much safer and faster if it were done by helicopter or small plane, but I guess if the car works then they don't have to use aircraft.

Completely depends on the organ. Kidneys can survive outside the body for 1-2 days, while heart and lungs only survive 4-6 hours and are typically transported via ground or air ambulance, depending on distance.

Source: https://www.organdonor.gov/about/process/matching.html#expan...

Actually a company called FlyBlade does helicopter organ transplants. You should tell your sister to reach out to them.

https://www.foxbusiness.com/markets/blade-nyu-langone-transp...