I'd imagine that if these parcels are not strapped down and the load shifts in flight because of severe turbulence, that could shift the center of gravity enough to result in a chain of events leading to a crash.
Limited loads could be secured in the passenger cabin using the same tracks. Whether or not that actually makes economic sense is a different discussion.
You can see this in action here: https://www.reddit.com/r/aviation/comments/8scjkk/ever_wonde...
Obviously, you won't want to do this for general cargo transport, but for "hey, we have a grounded plane, but transporting air mail gives great rates right now" situations?