I definitely hear that many of my more extroverted colleagues are taking the isolation and lack of social interaction quite hard. As a more introverted person (who has done long stints of working remotely in the past), I find coping with this part less problematic. Instead, the "co-homenaut" problem is harder to deal with, as I have two young children. (In this sense, I wonder if "co-isolation" would not be a more appropriate phrase, as "isolation" doesn't quite capture it!) Are there sections of the site more focused on this aspect, or could it be made more prominent?