1. Where are the high costs coming from? Distribution? Storage? People? Most of these seem shared for other drugs.
2. Blood transfusion seems to be one of the most common treatments there is (https://en.wikipedia.org/wiki/Blood_transfusion#Frequency_of...). Safety concerns seem to stem from so far unknown pathogens that are not tested for in the blood of donors.
3. Production facilities are every hospital. Nothing needs to be produced or what do you refer to?