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Can anyone summarize differences with previous work like

https://cseweb.ucsd.edu/classes/sp00/cse231/dynamopldi.pdf ?

The closest previous work would rather be Facebook BOLT I believe: https://github.com/facebookincubator/BOLT

Right, I misremembered what Dynamo does - from the Bolt paper references I see that I was actually thinking of Spike (https://www.usenix.org/legacy/publications/library/proceedin...).

Interesting stuff!

This is profile-guided optimization: you run your program, collect data on what code runs, and use it to optimize the layout of your program. Dynamo runs optimizations at runtime.

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