Zilog also makes the ez80, which is like the Z180 but runs at 50MHz and has a 3 stage pipeline, and it has a 24-bit mode.
On the 6502 side, there's the 65C816S which is the fully-static CMOS version of the 65816, which is a 6502-compatible CPU with a 16 bit mode and 24-bit addressing. The Apple IIgs had one, but its clock speed was limited to 2.8MHz so as not to compete with the Macintosh. Today you could build a machine with a 14MHz 65C816S and fast SRAM, and have a pretty beastly 6502-compatible machine.
If you don't care about socket compatibility you could simply load an 8-bit CPU in a fast FPGA. It will probably not be hard to run one at 100MHz or so.
Grant Searle's breadboard CP/M machine: http://searle.x10host.com/cpm/index.html
Spencer Owen's RC2014 modular bus-based Z80 system: https://rc2014.co.uk/ Highly active RC2014 discussion group: https://groups.google.com/forum/#!forum/rc2014-z80
Phillip Stevens' beautiful YAZ180 Z180-based SBC: https://github.com/feilipu/yaz180
z88dk, a Z80 C cross compiler with libraries and all sorts of useful things, which supports many machines: https://www.z88dk.org/forum/
Jon Langseth's LiNC80: http://linc.no/products/linc80-sbc1/
Steve Cousins' many different machines, some RC2014-compatible, some z50bus (LiNC80) compatible, some Z180 stuff, SBCs, a powerful "small computer monitor", etc: https://smallcomputercentral.wordpress.com/projects/
Alan Cox's Fuzix, a unix for 8-bit machines (including many of the aforementioned Z80 machines): https://github.com/EtchedPixels/FUZIX
Most of the folks mentioned can be found on the retro-comp discussion group, which was formed from RC2014 group members to discuss other projects: https://groups.google.com/forum/#!forum/retro-comp