Great! Probably one of the first managed languages to properly support RISC-V.
RISC
RISC II
SOAR
SPUR
RISC-V
https://www2.eecs.berkeley.edu/Pubs/TechRpts/2016/EECS-2016-...As for the original OG RISC, I think that'd be the Cray 1.
So I'll go with the Cray as being to OG RISC. But yes, firsts don't really matter except to say it sure wasn't the Berkeley RISC or the Stanford MIPS.
uLisp could also take advantage of cross compiling, the author just chose another path that allowed him the focus on other areas instead.
Also probably most interpreted languages work out of the box (Ruby, Python etc)
Interpreter languages is easier, given the existence of C and C++ compilers.