State projections for Covid-19
covidactnow.org
covidactnow.org
I get that right now we're buying time. My current understanding is that we're trying to slow the spread of the disease because the existing health care system was going to quickly collapse under the weight; whether or not that should have been the case or not is a discussion for another day. I also understand that we are -not- trying to contain the disease, just "serialize" its progression (so to speak) through the population.
Assuming that understanding is sufficiently correct, what I'm not hearing enough of is what is being done with the time we're buying. Many in the Hacker News audience likes to talk about "externalities" and how the wise appreciates those externalities in their actions. Shutting down the economy has externalities; those externatlities can be life or death as well. If the strategy of those implementing the "shelter in place" is one of just waiting it out: then I'm going to be off the wagon fairly quickly. I want to start hearing strategies that start to address the issues of how we minimize impacts of this problem. I want to know what we're buying for the pain that we're being sold on. I want to know when people estimate that the societal damages of the illness start to be outweighed by the damages of our response.
I see the admin of the site suggesting we're buying time for these things. I want to start hearing this from the officials making policy.
We are buying time to get more tests, more hospital beds set up, more ventilators, more medicine. The Navy is talking about turning Aircraft Carriers into hospitals. China is getting things under control and switching factories to produce medical supplies. It takes time to build these logistics chains, and we are buying that time by slowing our economy down and implementing social distancing.
I agree that this information is not well-circulated right now.
EDIT: another commenter posted this great link which I will also share: https://medium.com/@tomaspueyo/coronavirus-the-hammer-and-th...
When I went out for groceries this week (weekday late evening to avoid crowding) I was the only one in the store wearing a mask. Rationally I knew it was reducing risk for others but I still felt deeply uncomfortable being the odd one out.
Contrast this with places like Taiwan where a mask isn’t considered abnormal, and becomes a matter of course during times like this.
Catching a Corina virus with less than 15 minutes personal contact is very unlikely and it's extraordinary unlikely to be able to acquire a virion and get it to a host cell just walking past an infected perso on the street.
It's not even clear how infectious the surface to face vector is.
Italians and Spaniards running around kissing each other and rubbing cheeks as is their ancient custom likely has more to do with the issues there than anything
Masks are very hard to come by... that might be why it looks like business as usual? I'd love to get some myself, tips appreciated.
It's literally not okay to be wearing gloves in a chemistry/biochemistry building when you push an elevator button.
But I always tossed the gloves before leaving the work area. And usually I'd put on fresh gloves before removing the lead apron.
That wouldn't be workable day to day. You'd probably go through 50-100 gloves per day, doing it right.
My daughter is also sewing cloth mask using a pattern from https://www.craftpassion.com/face-mask-sewing-pattern/
I know these aren't as good, but they probably improve my chances of avoiding SARS-CoV-2 by at least 10% when I have to go outside. I plan on using them once, then leaving them in a bucket in the garage. Once I've used them all up, I'll wash them and by that time (and hopefully the detergent + bleach action), the virus will be dead.
It's no better than avoiding personal contact generally.
https://smartairfilters.com/en/blog/best-materials-make-diy-...
The main risk when getting groceries, unless people are coughing or sneezing in your face, is transfers from your hands, which a surgical or n95/r95/p95 mask does roughly zero to help with. (Now, getting everyone else to wear such a mask would reduce the odds of them contaminating something that would get on your hands, but that's not a benefit of you wearing mask.)
Several states fairly recently passed laws requiring food preparers to wear gloves. Then they backtracked when they realized that they actually decreased safety.
For the average person, a mask likely is an individual benefit. But in a world with insufficient masks and asymmetric risks, social benefit, literally the health of the public, benefits most by limited and targeted use.
Distinguishing between personal and communal risk is critical here. That message has been poorly conveyed, even by ordinarily excellent communicators -- Zynep Tufekci comes to mind.
My comment was in the context of "what can time fix", which would mean supplying healthcare workers and everybody else with masks before letting up. Retail workers wearing masks would go a long way to creating some peer pressure to act differently.
From what I understand the best prevention is to reduce face-to-face contact with other people where possible, but an N95 mask would definitely help prevent contraction in public spaces.
Of course, these measures seem extreme since ~80% of people will barely notice they are infected / have mild symptoms, but it's all about peak-load reduction.
[1]: https://www.youtube.com/watch?v=V1xBiBVH7U4 [2]: https://www.youtube.com/watch?v=E3URhJx0NSw&t=7s
It gives you very limited protection. There's no replacement for just avoiding people, 15 feet away from everyone.
They're mainly good for people who are infected to not transmit pathogens.
When doctors operate on infectious people, they wear hazmat suits. Full face mask, air filter and body condom. You can get a virus through your ears, eyes, mouth, nose, or microabrasions on your skin.
You can wear a mask, but I fear that people will start thinking it's anywhere near full protection. False sense of security is probably not worth even encouraging in a situation this dire.
- Gilead Sciences; remdesivir for treatment; currently in phase 3 clinical trials
- Ascletis Pharma; danoprevir/ritonavir for treatment; currently in phase 1 clinical trials
- Moderna Therapeutics; mRNA vaccine; currently in phase 1 clinical trials
- CanSino Biologics; attenuated vaccine; currently in phase 1 clinical trials
- Arcturus Therapeutics; hybrid RNA vaccine; currently preclinical
- BioNTech; mRNA vaccine; currently preclinical
- CureVac; mRNA vaccine; currently preclinical
- Eli Lilly; isolated antibody treatment; currently preclinical
- GlaxoSmithKline; vaccine adjuvants; currently preclinical
- Inovio Pharmaceuticals; DNA-based vaccine; currently preclinical
- Johnson & Johnson; attenuated vaccine; currently preclinical
- Pfizer; assistance with both vaccines and treatments
- Regeneron Pharmaceuticals; engineered antibody treatment; currently preclinical
- Sanofi; hybrid DNA-based attentuated virus vaccine; currently preclinical
- Takeda; isolated antibody treatment; currently preclinical
- Vir Biotechnology; isolated antibody treatment; currently preclinical
Most of these are in very early stages, but I'm optimistic that that speed of development of both treatments and vaccines will exceed the consensus expectations.
This, along with recent advancements in bioengineering will, I believe, lead to surprisingly rapid progress.
(The best current mouse models for human coronavirus are not very good; the mice are generally resistant to the virus, so it's difficult to determine whether a vaccine or treatment is working.)
https://www.statnews.com/2020/03/05/coronavirus-labs-scrambl...
https://www.statnews.com/2020/03/11/researchers-rush-to-star...
Worse yet is that if we let the measures off, we just get the same curve later. A bit lower at peak, but still exceeding healthcare capacity several times (say, 6x rather than 8x, if we do a 5-month lockdown).
But this still saves lives - just not anywhere as many as we could have saved if we contained it. It also gives us a chance to build more hospitals, manufacture more ventilators etc - although it still won't catch up with demand.
The best endgame is that we either get a vaccine, or enough tests to test everybody, and then do targeted quarantine from there.
Also locking down everything DOES stop the exponential spread. That's the whole point. If you don't see other people, you aren't spreading the disease, reducing the rate of new infections. If each infected person infects less than 1 other person on average, we'll have stopped the spread. China and SK have already succeeded in this.
This isn't exactly correct. It means that, eventually, the spread would die out even if there were an infinite number of potential hosts. But it's still spreading. If that number is exactly 1, ~everyone will still end up getting infected. If it's just a bit below 1, it will behave as a decaying exponential but will still take a long time to die out.
And I wasn't trying to dispute your claim that the "best endgame" is the goal, merely clarify it - and also point out that even then, we will still see our healthcare overwhelmed, and a lot of people will still die because they will be rationed out of the system. People who wouldn't have died if we locked things down when containment was still realistic - so I consider them all preventable deaths that we have failed to prevent as a society.
To be absolutely clear: a lockdown is still our best bet, and the lives it'll save are worth it.
Giving up and attempting to resume normal activity is also unacceptable, full stop.
The best/latest explanation I've seen is https://medium.com/@tomaspueyo/coronavirus-the-hammer-and-th.... Please read it (everyone, not just parent) if you haven't already.
Then if you're frustrated that your political leaders aren't moving to make best use of your sacrifice... let them know!
I will see what my MP has to say about it. Couldn't find a UK petition about it.
The details of managing the economics are more than a footnote, but if the worst possible peak isn't avoided everything else becomes irrelevant, because there's no surviving economy to speak of - except maybe one of local barter.
The economics are not externalities. The virus is.
The economics are a social and political choice. They don't actually require money or other symbols, although they'll probably be mediated through for reasons of comfort and familiarity.
They require enough basic provision of food and services to keep people alive, and enough provision of shelter to keep people from rioting, especially once winter comes.
The worst possible economic outcome - after a Killer Peak - is a critical mass of angry and hopeless people with nothing to lose.
Realistically, avoiding that will probably mean helicopter money and aggressive price controls to prevent gouging and profiteering. The usual rules about inflation won't apply because the alternative will be a cratering depression and mass deflation which will do far more harm to the economy than hand-outs will.
It may also mean something worse, like some form of civil conscription to get essential work done. I really hope that doesn't happen, not just because it's better to call for volunteers first, but because it's so easy to abuse politically.
But it's also true this has the potential to become the equivalent of a war time situation, and in extremis the rules may need to change to keep food+lights happening.
Shit choices. But it's a shit situation, and IMO there's no chance of business as usual returning for quite some time.
Perhaps the argument would be better stated: We need to balance saving lives and maintaining the thin veneer that is our economy.
That isn't quite as inspiring, but perhaps that is reality? Even if our economy is a "veneer" we still need it. I find it less compelling though. I'm far more willing to trade lives for a "strong economy" than I am to trade lives for "the illusion of a strong economy".
"Grandma and Grandpa died at home without medical support, but at least our economy is 'strong', so strong it could probably survive weeks of social distancing!"
If our "prize" for sacrificing hundreds of thousands of elderly to an exceptionally uncomfortable death is an economy we all know can't handle even a minor pandemic and is incapable of doing what China and other countries have done, that will be a sad trade.
The more interesting question is how much of our economy is literally waste. I suspect we'll find out.
What we’re learning globally to a greater or lesser extent is that our economies are not resilient. That capitalism of various kinds has failed us. And that when it comes down to it we need one another to give a shit about each other.
Unfortunately, even the best economic system can't disguise the fact that fewer people working means fewer products and services are available.
There are going to be trillions of dollars spent attempting to bail out the economies of the world.
Airlines, Bars, Restaurants, Hotels, Cruises, Conferences, Taxies, Hair Salons, Chiropractors, dozens more...
That's 10s of millions of jobs. Livelihoods ruined.
Maybe your job is safe. Mine too. But you have to put yourself in the shoes of someone who is being financially ruined, and whose life expectancy will likely be greatly diminished as a result.
There are major tradeoffs here.
Bars and restaurants will re-open, those are always in high demand, and easy to start.
Hotels have facilities and real estate that are valuable, and should bounce back once people feel comfortable traveling again.
Cruises can die in a fire. They've always been hotbeds of disease, and are now pretty much tainted.
Conferences might switch permanently to a virtual methodology as Apple is doing with WWDC. This could increase the reach of the conference since it's insanely expensive, as well as hard to get tickets.
Taxis (including Uber/Lyft), hair salons, all easy to restart, and demand will bounce back. Chiropractors are frauds, so I don't care if they fail.
A conference means people travelling, hotel rooms, meals in restaurants, good dresses, presents for the family... It may be better for society to make them on-line (it would be better for the environment, for example), but the economic impact would be huge.
It's interesting that paying people's rent for them is on the table, but denying rent to the literal rent-seekers isn't. As though ensuring those who collect rent get their rent is more important than keeping people in homes.
do you imagine every tenant's landlord is a literal scrooge mcduck?
my elderly neighbors rent their basement out. should they just be told they don't get paid for a few months?
my retired parents own REITs, and pay their bills with those dividends. if the real estate companies don't get paid, there's no dividends, and then my parents are buying cat food.
pensions and retirement funds across the country rely on rents coming in.
this "just suspend rents" line would be less insane if you'd acknowledge there are trade-offs to it.
Eviction/foreclosure bans have in many places been adopted along with shelter-in-place orders.
> Hard to practice social distancing in a homeless shelter and get access to adequate nutrition, especially if they become overpopulated
Why California’s emergency approach includes the power to seize hotels to rapidly expand shelter capacity (and why SF is in negotiations to buy hotel space for an extended time for that purpose.)
They are simply pausing evictions. So, you lose your job due to the pandemic and as soon as it has improved then you still get kicked out. I don't think that is much relief, especially if there is another wave.
Here is the order:
https://www.michigan.gov/whitmer/0,9309,7-387-90499_90705-52...
> Why California’s emergency approach includes the power to seize hotels to rapidly expand shelter capacity (and why SF is in negotiations to buy hotel space for an extended time for that purpose.)
All I've seen is for quarantine sites, not for shelters.
He ignores the "economy", he says that layoffs are necessary, which is to basically suggest that the economy will adapt.
And everywhere you have internet commenters "But what about the economy?" and citing serious consequences of recession/depression in order to criticize isolation/quarantine/lockdown.
Edit: Here’s the old paper from 2007 the CDC is using to inform some of the policy around “flattening the curve” below hospital capacity. https://stacks.cdc.gov/view/cdc/11425
I've been reading every whitepaper and journal publication I can find on this disease.
The picture that I'm seeing is that this disease is both more infectious (higher R0) and less deadly than previously thought.
In light of those facts I am fairly convinced the lockdowns and resulting economic impacts will be worse than just isolating the most vulnerable and letting the rest of the population go about their business.
https://www.medrxiv.org/content/10.1101/2020.02.12.20022434v... (Suggests the R0 is much higher and IFR much lower than reported)
https://www.epicentro.iss.it/coronavirus/bollettino/Report-C... (shows that the people dying are very old and very sick already. Also given the fact that part of the population is so impacted strongly suggests the disease is much more widespread)
Also, all of the celebrities, politicians and athletes that are testing positive are proof, in my opinion, of how wide this has gone.
I'm astonished how many people think that they know better how to respond than the professional epidemiologists. If anything the response actually enacted is tempered from what they recommend by the politicians.
If I should find some positive in this over-response, that would be the benefit for the environment due to less pollution. If we could reduce emissions to the current level, the climate would be so much better for it.
The problem with this disease is that while many people don't die, they require intensive care. As we can see in Italy currently this will overwhelm hospitals at some point (and Italy has already put drastic measures into place). At that point it becomes a huge problem for society: a lot of people are dying and the health system doesn't work anymore. People die because of appendicitis etc.
We will all catch this unless we stay locked up until the vaccine comes.
So, expect everyone to catch it.
Obviously travel etc. gum up this plan but instead of containment or mitigation we can move to a "time gapped reset" policy that predicts a continuous growth/halt cycle for the virus instead of pointlessly trying to eradicate it completely.
Loss of life to the inner vs loss of life caused by economic consequences, I've seen that argument before and it's not entirely unappealing. But wherever I saw it there was the unspoken assumption that the economy would just continue completely unaffected by an uncontrolled epidemic. But much of the economic damage will be there no matter which path you take. There are likely same areas where a short, hard wave would even be worse, economically, than a controlled lockdown. The delta is even harder to estimate than the cost of slowdown strategies, but an argument that only looks at the economic cost of one option is flawed.
Personally, given the choice, I'd take option C, "show me a rerun of 2019". Unfortunately this isn't in the cards that we are dealt.
I think the problem with this very common attitude is the demand for immediate answers, or else. It's an ultimatum.
We don't expect programmers and engineers to come up with complete, ready-to-commit solutions to a complex problem immediately. Thinking like a consumer doesn't help. An alternative is to demand transparency and to be engaged in the process of decision making. But that requires an attitude/intellectual realignment.
What's concerning about the current messaging is that it's not clear whether it's incorporated the underlying limits to how long people will tolerate a lockdown. An ultimatum is the right framing; decisionmakers need to know, and we need to know they know, that "then we'll lock down for 6 months" is not part of the solution space.
Most people aren’t willing to explicitly discuss how many lives it’s worth to be allowed to hug your mother, so for general consumption it must be framed in absolutes. There’s a number of weeks past which the cost is unacceptable and I’m joining the mob at City Hall, and that number is not in the double digits.
This was along the lines of my first thoughts as well. Theoretically, we want to maximize the usage of our medical resources (personnel, reusable supplies such as bed space, non-reusable supplies such as medication that become available at a variable rate), to keep just enough below the capacity to handle the needs and allow for some spikes (if we can even get it that low).
To my eyes, that calls for the ability to reassess and shift directives for the public (that is, maybe ease up on shelter-in-place next week, but put it back the week after), track and optimize resource flow, and coordination between locales. As a national level emergency, it makes sense there would be national level coordination on how to deal with it. Instead it appears we have governors and mayors making their own calls on what to do based on what advice they are personally getting, and the health care system is just struggling to figure out what to do.
What we don't have is any leadership putting forth an actual plan, or any real indication that they are even attempting to do so, or that if they are that they're putting any real teeth behind making sure officials are on board.
And no the vaccine is still too far in the future so the idea that the lockdown is biding time until the vaccine is ready is ridiculous.
Why have we all (I'm speaking for people in the USA) immediately bought into the idea that shutting down out lives and the economy is the only way to combat this thing? South Korea didn't shut everything down in an authoritarian fashion, and they already have this thing beat. I know, not a fair comparison, USA is way bigger, less experienced in handling disease outbreaks, different governments, etc, etc. But aren't there smarter ways we can handle this than just blanket isolation & lock downs?
From the CDC:
"Pandemics begin with an investigation phase, followed by recognition, initiation, and acceleration phases. The peak of illnesses occurs at the end of the acceleration phase, which is followed by a deceleration phase, during which there is a decrease in illnesses. Different countries can be in different phases of the pandemic at any point in time and different parts of the same country can also be in different phases of a pandemic."
So we know from South Korea's example it is possible to hit acceleration phase, execute a smart plan of attack, and have it carry you into deceleration, without blanket lock downs. Lock downs can still be an effective tool, and should be used in areas seeing steep acceleration to take pressure off the medical system.
Our plan doesn't have to be exactly the same, but we can learn from theirs. Seems like nobody is even trying to think out of the box. We just accepted that we have to turn our country into an authoritarian state and that's the only way to beat this.
Focusing on making testing widely and easily accessible is key for sure. If people could easily get a test, it would eliminate a lot of the fear/ uncertainly that is gripping everyone. Healthy people who are at low risk to get severe reactions could go about there lives normally, while still practicing 'social distancing' in public, not locked away in their homes in fear
Not if you don't have as advanced infrastructure, quick government, and decisive politicians like Korea, and 1/4th of the country is in third world conditions regarding access to healthcare, or even shelter, etc.
You don't need tests for that, just common sense. If you have low risk, by all means keep working while keeping high sanitary precautions. It's unrealistic to expect all people to stay at home, hence those of us who are likely to get a mild COVID-19 case should make sure the people at risk or already sick have services while they stay at home.
If you're healthy, take precautions and still get COVID-19, after recovering you become another line of defense with your new immunity.
That being said, tests are very important, but don't wait for free and widely available tests to decide if you can keep working, your circumstances decide that.
You're allowing people to get infected, but reducing the rate at which they get infected, thus allowing your healthcare system to cope with the demand while the rest of society slowly builds immunity.
My girlfriend’s brother in-law owns a large, successful restaurant in the city next door. They city has only 1 confirmed case, and that guy got it from traveling to Italy. Still the governor threw a blanket ban on restaurant dining rooms, and they are forced to lay off most of their workforce.
I doubt his business will fail, but he told me he already knew of two other restaurants in the city that already went out of business because of such low traffic even before the lockdown. Seems like we should implement these bans in a more targeted way.
Sorry you are inconvenienced.
* Rapidly expand healthcare capacity
* Develop a vaccine
* Build out a testing infrastructure that allows for targeted containment, rapid response, and chain-of-infection tracing without needing a full lockdown
With enough testing and sufficient frequency of testing, isolating just the people who test positive (and perhaps their contacts) should be enough to stop exponential growth, which means we could mostly return to normal life.
I liken it to the immune system. Shutting things down can work for a short period but if the system goes into a full panic it begins attacking good cells and shutting down organs and the host dies a slow, painful death.
We need to be using this bought time to building medical equipment, beds and places to put them, manufacturing existing therapies to help, training people to use specific equipment, creating a system for the most vulnerable to quarantine but get food, medicine, safely as they wait for acceptable safety to them.
We can’t lock down for months and months. People will eventually be fed up, see their risk is low, and throw the dice. The economy can’t grind to halt for a long time.
We need to prepare to minimize death and we need to do it now. Lockdown is not much of a strategy or something that will work beyond a few weeks before people ignore it massively.
Would this work for ya?
But the question in your third paragraph "what is being done with the time we're buying" could be restated as "what are we getting for our loss in economic output _in terms of economic output_?' That's not what we are doing, we are giving up economic output, not getting it. Of course any schemes/inventions/techniques that increase the coefficient of return of this trade off would be welcome, but doesn't change the fundamental direction of the tradeoff.
And that's not to say we are doing nothing at all with that time. Maybe we have "more time to develop a vaccine", or "time to make ventillators."? But those _are_ economic outputs. Those actions trade back lives (via increased transmission rates) for production of utilities that we believe will save lives in an equation that nets a positive. And it's not to say that people won't do some productive things during this (like the memes of inventing calculus in isolation or whatever), but for sure society is reducing it's overall economic output.
So from this point on the questions (and threats of defection) you raise kinda presuppose that trading economic production for saving lives is not worth it (at whatever ratio you're expecting). Potentially this is because you expect higher economic costs/lower life savings than the generally accepted projections, or because you value life less, or you believe the economic loss will lead to greater loss of life long term. I think the burden then is on you to either produce better projections, or promote candidates into government/leadership positions that share your moral outlook, or formulate and promulgate a model that shows the dramatic effects you expect due to the economic loss.
To put it another way, a simplified answer to 'what are we doing with the time' could be 'approximately nothing', and our society at large seems to be on board with that trade. If you're not, change my/our mind.
That's not true. Even with massively ramped up hospital capacity, we'd still have to spread it out over years to support the whole population getting sick. And realistically, if you can keep the disease progression spread out over a long period of time, it means you've stopped the exponential growth (i.e. R0 <= 1), and it isn't that much harder to actually contain it.
What we want to do is to contain it using blanket measures until we can get our act together with large scale testing, contact tracing, and basic sanitation measures (e.g. general mask wearing, hand-washing, and social distancing by the public without needing to lock everything down). This was where China got to after an early lockdown, and it's where South Korea has always been (without the need for a massive lockdown in the first place). Then in a year hopefully the disease can be stopped altogether with mass vaccination.
Keeping in mind that something like 80% of people will only experience mild symptoms, does this assertion still hold?
a) Saves millions of lives.
b) Allows researchers to develop, produce and distribute a safe vaccine.
Medium term, we can more properly organize and distribute medical resources, assemble temporary hospitals, learn more about current anti-virals to better manage it, etc. Allowing even more steps towards normalcy.
The vaccine is immensely important, but there are major steps before then that we don't have to be completely locked down waiting for.
Universal Mask Wearing Is the Quickest Way to Restart the California Economy
We urgently need universal mask wearing to slow down the spread of COVID-19 and restore our economy.
This is CDC's advice on how healthcare providers can protect themselves if they suspect that a patient has COVID-19:
" Assess and triage these patients with acute respiratory symptoms and risk factors for COVID-19 to minimize chances of exposure, including placing a facemask on the patient and placing them in an examination room with the door closed." (What Healthcare Personnel Should Know about Caring for Patients with Confirmed or Possible COVID-19 Infection https://www.cdc.gov/coronavirus/2019-ncov/hcp/caring-for-pat...)
If a facemask on a patient can protect the doctor in close proximity, it surely can also protect the general public. Yet the message from our nation's leadership is that mask wearing is ineffective for the general public (Why Telling People They Don’t Need Masks Backfired https://www.nytimes.com/2020/03/17/opinion/coronavirus-face-...). Yes, it is not 100% effective in protecting an individual from others, but it is absolutely effective in protecting the general public from a potential patient. This is the herd immunity we can quickly achieve without waiting for a vaccine:
"An 80% compliance rate essentially eliminated the influenza outbreak. " (Modeling the Effectiveness of Respiratory Protective Devices in Reducing Influenza Outbreak https://www.ncbi.nlm.nih.gov/pubmed/30229968)
California is in a unique place to lead the nation and restore its own economy. We have a large Asian population that are receptive to mask wearing but are wary of being singled out. We have technology companies that can come up with solutions for mask making. We have idled workers that can be quickly retrained to jumpstart mask manufacturing. China was able to ramp up production 12 times in February alone. We can do it too.
What we need to do is to legally require people to wear masks in public and in the workplace to protect each other. We don't need to wear N95 respirators that are hard to use and that should rightly be reserved for medical workers; we can wear masks that are much more breathable to protect others from our own droplets. By making it a legal requirement, companies like Tesla will be motivated to either quickly secure masks from suppliers or, better yet, start making and supplying masks for their own employees and for the public. Asian countries have shown that universal mask wearing can prevent large outbreaks and slow down the spread of the disease without shutting down their economy. Let's learn from their experience. Governor Newsom should immediately work on this with the state legislature in order to lead us to a speedy recovery.
Right now there's a huge shortage and we still have a very small number of cases--it's all people stockpiling and using them where it's not as critical.
Like you say, after we can replenish the supply I'm sure it will be more commonplace.
[0] https://medium.com/@matthiassamwald/promoting-simple-do-it-y...
But right now no government dares suggest any vision past a few months.
By winter we'd have more equipment, masks, drugs tested, doctors taking a break, etc. The big spread also stops in warmer climate.
>World governments should clarify this matter by saying that a bad winter resurgence, months after nations are fatigued with lockdown, is definitely not going to happen.
Of course it's possible and very likely to happen. The answer is not no lockdown, it's a second lockdown then as the need arises.
- R0s for interventions are guesses, in some cases informed by data. There is no historical precedent for what is going on right now to draw from.
- The default R0 used in this model is an average. The model does not adjust for the population density, culturally-determined interaction frequency and closeness, humidity, temperature, etc in calculating R0.
- This is not a node-based analysis, and thus assumes everyone spreads the disease at the same rate. In practice, there are some folks who are “super-spreaders,” and others who are almost isolated. Interventions should be targeted primarily at those most likely to spread the disease.
Are there any epidemiologists using less naive statistical models who are producing easily readable results like this? The "average R0" logistic function model seems better suited for examining historical epidemics than estimating risk to inform decision-making for ongoing epidemics.
And most if not all scientific and engineering models spread properties across a group of objects and use averages. R_0 is an average. And it's the average behavior that matters here
In a well tested population, you might be able to focus interventions on infected people and their contacts. In the US population, the people most likely to spread the disease are those who interact most with other people. That means getting those people to reduce their interaction rate.
It's a semi-empirical model, as are many if not most models used to make decisions.
That said, the implication that strict isolation should be maintained is almost certainly correct.
Interestingly, the model is not nearly as sensitive to R-values as you would think, until they get under 1.5 (half the current observed number in most places).
See here: https://www.researchgate.net/figure/Doubling-time-Average-do...
I say this as someone that thinks they had it a month ago. I was on steroids for a week, then a respirator, then steroids for another week. Worst asthma attack of my adult life. I live in Seattle... (And yes, i had fevers)
I did not get tested, but having a hard time shaking that I had it. And if I did, so has my family. With my kids all having fevers, but no shortness of breath.
Edit: I hasten to add that I am socializing this as a call for what am I missing? I am not encouraging inaction.
Studies of SARS showed that regions with high pollution were significantly more at risk for death from it. If that is the case for this, the severity expected in many parts of the world will be considerably lower than projected.
Again, stay home. I am not encouraging breaking self distancing. The panic message is worrying me because everyone seems to only be looking for reasons to panic.
The symptoms as a whole didn't quite feel like a flu, we all thought they were weird, but hey who am I to know, right?
Well a few weeks later we remembered that two days prior to feeling ill, we had ordered some Chinese takeout. The delivery man (not a Chinese national) looked like he was going to collapse. He had trouble getting up the stairs, had a bad cough, looked like he had a fever - god knows why he was working. After taking the food and paying, I wondered if he'd make it back down the stairs but forgot about it for a few weeks.
We probably won't know if we had this bug or not, but it's definitely possible. Maybe I just happened to develop a respiratory distress caused by a bad flu right when the epidemic in China was not controlled, and not any other year prior. Who knows!
Right now, as I type this, many hospitals in the United States have had all of their excess intensive care capacity used up by Covid-19 cases. Not all, but many.
Once large groups of hospitals reach capacity, then there will be no choice but to black tag people who could otherwise be saved and leave them to die in the hallways.
Click this graph, then click Logarithmic at the top: https://mackuba.eu/corona/#united_states
You're right to note that this is a global problem. Given that, the vast majority of human to human contact is NOT cross border.
This bug is probably going to end up infecting most of the people in the United States. The main thing we can do at this point is to keep hospitals from being too overwhelmed, to keep the number of black tagged people, dying in the hallways, to a minimum.
Exactly. As you say, we need to flatten the curve to keep hospitals from becoming overwhelmed, and we need to use the time to develop treatments to save the vulnerable when isolation eventually fails.
Do you happen to have a source for this? I haven't heard much about hospital problems yet.
Perhaps this reduces the infection rate.
[1] https://www.forbes.com/sites/brucelee/2020/03/18/what-percen...
If a person get good care in hospital the rate of survival would be totally different.
For those country which had sudden high fatality rate was because their resources and supplies were exhausted - there were no bed, no consumable, even no protection for the nurses.
Now the really terrible part is that the economic effect of the mass closure is going to grow exponentially. So layoffs start small and grow more massive week by week. And unlike COVID-19, that economic effect will not subside with the warming weather...
Here is some evidence:
Compare the slow growth in cases per day (green line) in CA and FL (warm) vs NY and WA (cold):
https://covid-19.direct/state/CA
https://covid-19.direct/state/FL
https://covid-19.direct/state/NY
https://covid-19.direct/state/WA
See for example how in Malaysia there was an outbreak due to a very large Muslim gathering with foreign travelers, that seems to diminish every day (indicated an R factor < 1) - https://www.worldometers.info/coronavirus/country/malaysia/ The same is true for Qatar.
Same examples all over the world for warm countries: https://www.worldometers.info/coronavirus/
The point is that places like California will experience slow growth which will also decline quickly with the warming weather, not that every place has negative growth right now.
Maybe you should read this from an actual epidemiologist: https://ccdd.hsph.harvard.edu/will-covid-19-go-away-on-its-o...
The article is explaining what the default assumption should be. Empirical data might change that view.
My critique of this analysis is that there is no way you are controlling for all of the factors: different starting dates for community spread, uneven testing / reporting of cases, random luck due to super-spreading events, differences in behaviors between regions, and so on.
Which is to say, I accept it is complicated. If it correlates with something, that is just another question. Not likely an answer in itself.
City density, by its turn, is huge.
This is missing a HUGE point. At the very end of the California "shelter-in-place" plan, the numbers will go up. What it doesn't show is that this will merely delay the epidemic to 3 months in the future. The chart useless with only a 3 month time horizon.
> * A second spike in disease may occur after social distancing is stopped. Interventions are important because they buy time to create surge capacity in hospitals and develop therapeutic drugs that may have potential to lower hospitalization and fatality rates from COVID-19. See full scenario definitions here.
If you put the information in the footnote into the table, it makes the table harder to read.
As it is, the footnote is right below the table (not at the bottom of the page) and the information about the second spike is BOLD. That stands out to me.
In the end, that's likely what we'll have to do anyway. But it'll take longer than 3 months.
I wonder if that's accurate. I also wonder if this is recurring in the fall, and every year, and whether physical distancing will be mandatory every year?
Of course the above assumes that immunity really does develop after one exposure, and that the virus doesn't mutate into some sufficiently different form to reset the immunity counter to zero again. The evidence seems to indicate positive things on the immunity front, but it's still preliminary. And as for mutation, who can say?
And it's been a while since American legislators have considered the possibility of torches and pitchforks, so they still prioritize their electability (especially in the primaries, where ideological purism is more important) over social necessity.
The key is to buy time, now. To add hospital capacity, develop therapeutics and vaccines, and learn more about the disease...
Edit: Oops, brain fart. Those numbers don't include all cases, just hospitalized ones.
Yes, that's exactly right, but 3 months (or even 1 month) may be enough time to prevent unnecessary deaths by preparing hospitals, getting more ventilators, rolling out testing, and hopefully finding a therapeutic drug (vaccines are probably farther off).
Nobody can predict the future, though.
Pervasive testing looks like the best short-term hope right now - it's easier to drastically ramp up test manufacturing, and you don't need a full-fledged hospital for mass testing.
https://www.dallasnews.com/news/public-health/2020/03/22/hos...
> Our models show that it would take at least 2 months of Wuhan-style Lockdown to achieve full containment. However, it is unclear at this time how you could manage newly introduced infections.
When will Wuhan accept travelers from Spain or Italy ? Or are we going to live with border controls & quarantines forever?
EDIT: I'm talking about the doubling rate of the actual cases, not the confirmed cases.
New infections are modeled to noticeably slow down once ~1/5 of the total population is infected, but at that point things have already fallen apart.
Also of note that 30% daily increase I spoke of underestimates the difference between March 1 and March 20th.
Unfortunately, the US is further along the curve than all these sites are showing due to the fact that we didn't have any testing in the beginning (and still don't have enough).
Basically every state has measures in place already. None of that is reflected here, and there is no way to tell where it fits relative to the scenarios shown.
I have not seen any numbers to indicate Utah was at 96 hospitalizations as of yesterday. Are other state's number correct? Was California at 952 hospitalizations as of yesterday?
Is this just using number of cases as hospitalizations?
They seem to be opening stores, starting flights to SFO, but surely China is not clear of the virus. So, are we expecting a pick up in infections now. And, if not, please explain why not.. I'm really curious..
I get the impression that it's BS to say "look at South Korea and China, they're beating the outbreak and will soon be able to relax because they have lots of testing and transmission tracing". I haven't heard a single expert suggest that a "second wave" is avoidable at this point. It might have been avoidable if the whole world had reacted quickly and decisively in the early stages, but that ship has sailed.
The CDC also suggested that China was reporting falsified data in January (not surprising). Why should we trust their numbers now?
Exponential curves are easy to stop as long as you catch them early.
It's just not so clear it's possible to do such a lockdown in non-Authoritarian, free, countries.
Besides, the worst lockdowns have only just begun recently. There are a lot of people who will go ahead with, say, a 2-week lockdown, but will balk at 3 months. The true test for the ability to maintain things that way is still ahead for Western countries.
The most optimistic outcome, for me, is that remote work becomes a bigger possibility when companies realize they're wasting tons of money on too much office space.
People already know that we can live with less. _Businesses_, however, do not realize this. I hope businesses ( especially big ones ) realize this.
Shortcomings in our economy and health care ( not just America, but world-wide ) will be realized and fixed.
However, I do not think any of the above will become true. Humans have short memories. I think once the crisis is over, business as usual will resume and we will have made no progress. Other than another vaccine.
https://covidactnow.org/data/{{state_abbreviation}}.{{scenario_number}}.json (where scenarios go from 0 - 7)
My question is this: what would you propose we do? If we don’t lock everything down, we’ll overwhelm the hospitals and the death rate will skyrocket. And then the deaths will be less skewed towards the elderly, because virtually all causes of mortality will shoot up when we no longer have a functioning medical system to treat anyone for anything except this.
Are you really proposing we just let hundreds of millions of people all over the world die over the next 6-12 months? So we’ll all just go back to work and to restaurants and on vacation while 5% of the population is gasping their last breaths in a hospital somewhere? We’ll just say goodbye to a huge chunk of our parents and grandparents and aunts and uncles and coworkers? Because the economic cost is just too high?
It’s easy to complain about this course of action. It sucks. But unless you can lay out a plausible alternative, this still seems like the best one to me.
There are some questions on if there was really going to be a curve to flatten. Such that, if we flatten it now, was it the social distancing we did, or was it going to flatten anyway?
These are not reasons to abandon caution. They do seem valid questions, though. Especially considering the costs of the actions we have taken.
Agreed, but a lot of people are arguing for the thing that will almost certainly lead to a lot more deaths.
Right now, as I type this, many hospitals in the United States have had all of their excess capacity filled with Covid-19 cases. Not most, but many.
Now, please click this link, then click Logarithmic on the top.
https://mackuba.eu/corona/#united_states
Once large groups of hospitals reach saturation, people who could otherwise be saved will be black tagged and left to die.
Two women my wife is Facebook friends with, after two weeks of a mild fever, malaise and a moderate, unproductive cough, started having a hard time breathing. They went in and were both positive for Covid-19. They were placed on ventilators, and were soon in critical condition. One of them died this morning, the other is clinging on to life.
Neither of these people are old; neither of them have any substantial medical history or other comorbidities.
This bug is dangerous for all of us; it's extremely dangerous for some of us.
It's true that few people are soberly thinking about the mid and long term economic cost of this pandemic. In my opinion, there's a good chance we're facing something on the order of the great depression.
Be that as it may, lives must come first.
Today Santa Clara county has 65 people hospitalized:
https://commons.wikimedia.org/wiki/Data:COVID-19_Cases_in_Sa...
In comparison, Stanford hospital has 600 beds:
1 - https://stanfordhealthcare.org/content/dam/SHC/about-us/bond... (page 5)
2 - https://www.seattletimes.com/seattle-news/health/short-staff...
Edit: source is my wife who used to be ER nurse and then ER nurse manager in several Bay Area hospitals.
BTW, with the amount of people going back and forth between Bay Area and China, I have hard time believing that we had no cases in Jan/Feb. I personally know two people (and I met with both within a few days after their return) who came back from Wuhan in Dec and early Jan. A lot of people were sick in late Dec and early Jan with very similar symptoms.
So, to that end, I suspect I had this. It also went through my entire family of six. Nobody else even got sick enough that we would have help them home, except the had a fever that lasted a night.
So, in not arguing this isn't serious. If you have trouble breathing, get help. Immediately.
I'm growing less confident in all of the simulations I'm seeing of it's out of control growth, though.
Why? Because from all reporting, I almost certainly had it. And if I had it, my kids school was almost certainly saturated with it. Such that I think of there was going to be exponential growth in cases, that skip sailed over a month ago.
More likely: you didn’t have it.
I also just was told the Z-Pak I was put on is similar to what treats this. So, really not sure what to think. But my entire office was put sick for the month leading to this. My neighbor is the one that told me about the medicine, since she just finished a round.
So, maybe? Our hospitals are not seeing influxes if severe cases. They are getting swamped from panic and lack of supplies, from what I'm seeing. Not severe cases of people about to die.
Why ? Model have to fit what we observe. And we always observe exponential.
There are other fudge-factors as well. There is evidence that the very early stages are not exponential, but possibly quadratic or some other curve, but this doesn't matter very much in the grand scope of things.
If you want to be really pedantic, you have to do Monte Carlo simulations using census and geospatial data for each area, factoring in things like school days, work hours, mass transit usage, and tourism.
However, it turns out that after all that effort you end up pretty much with a logistic curve, the first half of which is barely distinguishable from an exponential curve.
All previous pandemics and plagues have followed curves like this.
There is no magic math formula that will dispel this plague. Sorry.
My favored hypothesis on exposure to local pollution does a decent job of explaining. That said, so far every curve people are looking at assumes all nation's curve should be the same. But they aren't. Not even the cruise ships we have locked up have followed Italy or China style patterns.
I've been there on month-long holidays for the last three years straight, and the thing that struck me as the most alien was their borderline obsessive hygiene and cleanliness.
I'm sure you all know that Japanese people take their shoes off when they enter a house, right? Well, the Chinese recently discovered that coronaviruses can live on pavement for days in cool weather, and people track the viruses into their apartments on the soles of their shoes. The kids and pets roll around on the carpet, and presto... everyone in the household gets The Plague.
Shops in Japan package everything. If you buy a single strawberry mochi for about $1, it'll come in a tiny little plastic container, which they will put in a little paper takeaway bag, which then they will hand to you in a small plastic shopping bag. They sell individual bananas in plastic shrinkwrap. I shit you not.
All this while the cashier wears gloves and a facemask as standard, way before the coronavirus was a thing.
The bus and taxi drivers all wear white gloves. They have doilies on the seats, and I bet they wash them daily, given how pristine and white they looked.
At shinto temples, the first thing you're meant to do before entering is a ritual washing of your hands with fresh springwater. Then, of course, you take your shoes off.
It goes on and on.
Meanwhile, I regularly see people in shopping centres here coughing their lungs up. On to each other, the food, or just generally into the air to spice things up a bit. We're playing Pandemic Legacy on hard mode.
The cultures are entirely different, and Japan basically didn't even have to change anything to prepare for the coronavirus. They just kept doing what they're doing already...
And you didn’t answer my question. What is your plan?
I am seeing tons of extra reasons to panic every day. Not much on why to stay calm. That worries me.
For my plan? I'm taking the safe route for now. Though, I'm 99% that I had it a month ago. Week of steroids, then a respirator, then another week of steroids. Not tested, as I wasn't in the then current risk profile. Would be today, if even close to those symptoms.
Now, if I'm at all close to right, my entire family of six didn't even bat an eye at this. Why? Have we drastically misstated the risk pool?
Again, my plan is to take the safe path. Is an easy plan for me, as I can do so. Large parts of our nation can't.
Apart from that, it's not like there is no economic help. In Germany, for instance, there is a rather easy process for the employed as well as businesses to get state funding. So it is not like most businesses will go under or people lose their houses.
Regardless, we obviously can’t execute on it, for reasons of incompetency, culture, faith in government, etc. And even if we could, it would take months to scale to where we’re testing millions per day like we’d need for that strategy. Millions would die by then.
So given where we are today, and the resources we have today, what would you do?
In a couple weeks/months they'll start testing people to find out if they did have the virus. The tests right now only show if you currently have it. Once the real numbers come out I am confident it will be a massive over estimate for the CFR.
The fear bubble is causing people to underlook the data in places like SK, SG, Japan, Germany and overlook the data in Italy, China, Iran. It could be quite possible that a mixture of smoking, age, over reporting causes, and bad healthcare (gasp not in Italy where socialized medicine is world beating) is being overlooked.
So what we get now is stopping of society and the economy, millions of people will go through displacement and a host of negative things. People's savings will be depleted, not to mention teacher's/public servants/ pension and 401ks will take a MASSIVE hit. Oh and add to that more trillions of USD to the debt.
I think in this situation fear is good, it ensures urgency and assists with decisive action making, coupled with humility to change course when your wrong. Apathy is much scarier than fear in these situations.
Also, the idea the economy will just keep rolling along somehow if we don’t do anything to slow the virus is wrong. When people are dying in the streets due to lack of health care capacity you’ll see what a real panic looks like. The economy is going to hard stop, probably including the food supply chain.
So the argument that stopping the economy now to help it later, eventually, even if we don't know how long we will need to keep it shut doesn't make any sense imo. We are jeopardizing our future ability to fight against the disease, big time
Just let 5% of your population die and tell the rest to get back to work, restaurants, vacation?
Also, you've literally ignored all of my argument that addressed what would be better and why it would be better. You also shifted back to a rhetorical question to avoid talking about whatever you said about dead people in the streets. It's absurd to move the goalposts like this.
But even if you are clearly being dishonest here, I'll say it again. The best option would be to not lock down the vast majority of the population because it will only mean less resources to help the sick and fight against the disease itself. It will also only lead to a breaking point where people will simply not be able to afford to stay on lockdown no matter how bad it gets. That will make the whole thing much more deadly because people will simply not follow any measure if they are hungry or completely broke.
There isn’t some magical good option or plan here. It’s a choice between terrible, terrible options, and you’re sticking your head in the sand and ignoring that.
https://www.bloomberg.com/news/articles/2020-03-18/99-of-tho...
It sounds like your plan to deal with an exponential outbreak is to wait a few weeks until you have better testing to see if this is really something to worry about, or if those disaster countries that came before you were just a fluke.
Do you not see the problem here? No one is suggesting we don’t test. But the disease is rapidly spreading while we dither about, and if you’re wrong about the CFR, it’ll be way, way too late by the time we know that.
The others countries have all had debate on optimistic vs precautious solutions, buying time vs saving the economy, but the reality is that none are able to correctly assess the spread of the virus. They can’t do correct science.
We can talk dream scenarios if this actually impacted the youth. Because in that case then there’s actual risk to future societies.
Have you seen an actuarial table for a 70 year old? Go ahead and tell me those numbers and how they compare to the sub 1% CFR seen in Germany, SG, South Korea and Japan.
If you accept that premise, then the only solution is to manage hospital capacity. So I propose that we use hospital overload as a high watermark for quarantining the local communities. so basically you initiate quarantine when hospitals are say at 50% of their capacity (because they will peak after quarantine begin). Wait & once they fall below say 10% release the quarantine. Repeat the process until you get herd immunity or vaccine.
Lastly once we go through a couple of these on-off cycles it will help establish that the virus is a know quantity to the larger economy so we can plan around this. which is way better than current 'OMG we are headed for depression' style panic.