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Only if you are far enough from retirement, or have enough assets, that you can handle the risk. Same as any other period.

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20+ years to retirement

For reference the typical advice for risky allocations is at least 10 years, but longer is better.

+ you are sure your job is secure enough that you won't need the extra cash as cushion before being able to find another job.

This shouldn't matter at all, since there are huge penalties associated with taking money out of your retirement funds before you're 59 and a half years old.

If your job is not secure, you should account for that by increasing your emergency funds (typically a savings or money market account).

There's not always penalties. Look up what's called the Section 72(t) distribution. This is a "retire early" option, where you can start taking a monthly distribution at any age, without penalty (income tax still applies), as long as you maintain that distribution for the longer of five years or until age 59.5.

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