From remarkable website:

Does the reMarkable adapt to left-handed people? If you're left-handed, don't worry. A few of our colleagues are also left-handed. They want to make sure all lefties have an excellent experience with their reMarkable device. You'll be able to set up your reMarkable to left-handed mode when you first set up your device. We've also made it easy to switch between right-handed and left-handed modes in the main settings.