Another downside to it is EMI. tying all the wires tight together increases the odds of any EMI problems vs letting them be loose in the wire duct.
In a previous CNC machine, I zip tied everything together very carefully, but was getting phantom steps in one of my steppers (even with shielded wires). Unclipping the zip ties caused the problem to go away. (after that, I added plenty of ferrites, too, as a measure of safety, but clipping the zip ties killed the only real symptom)