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n=45 Link to study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)...

The “graphical abstract” wonderfully distills the study design and results.

https://marlin-prod.literatumonline.com/cms/attachment/a9753...

I hope more papers do this. Is it required by Cell?

Low N is still interesting. If anything, it can help justify larger studies along the same lines, since there are costs for a study and researchers have to make their case to get the funding.

It isn't "Low N" though. 45 adults for a clinical study like this one is actually a very respectable size, particularly given their measures (and their respective reliability/studies backing them).

Seems like every study I read non-science people accuse it of having too few participants, without even considering the type of study (clinical Vs. statistical) and measures (subjective Vs. objective, reliability, literature, etc).

This is not a "Low N" study. If you believe it is then explain the statistics or methodology problems.

Yes, that too. Also it's important to realize that each study is a datapoint unto itself, and over time these data points paint a picture. But even if the study is not the whole picture, we can still get a hint as to what that picture is shaping to be.

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