1. In India, there are only ~100 jobs for a Clojure developer. That includes people just throwing in Clojure just to hire Java/Scala developer.

2. The learning curve for the Clojure. Clojure is simple but it's not easy by any means.

3. JVM interop if you are not a java developer it adds in more learning time. Most of the Clojure libraries use java heavily. It's a good thing but it adds in an extra layer of learning java's ecosystem.

4. Error messages. Even after years of Clojure. I still find it hard.

5. Documentation. Most of the packages I use don't have dedicated websites or good documentation.

Even after all the issues. It's still worth the investment. I started working on a crawler for a freelance gig. we first built it using Golang. But due to its complexity and lots of bugs due to mutation. We ported it to Clojure and we are not looking back.