> it's too expensive to resequence every time we need to run such a reanalysis algorithm.

You can also send hard disks to customers with the exome on them and ask them to either send them to you for a, idk 20 USD reanalysis that you recommend doing every year, or you can even have it done on the customer's computers themselves with a program that you provide that downloads the latest database of variants from the internet and then performs the analysis completely off-line without sending any info on which disease chances the patient has to you.