Japanese woman confirmed as coronavirus case for second time
reuters.com
reuters.com
>A biphasic course has been described in many patients, with an initial illness followed by improvement and then subsequent deterioration. This worsening can present as recurrent fever 4 to 7 days after initial defervescence, new chest infiltrates, respiratory failure, or watery diarrhea. In a cohort of 75 patients in Hong Kong, 85% had recurrent symptoms after initial improvement. The authors described a triphasic course with fever, myalgia early in week 1, and recurrent fever, hypoxemia, diarrhea, and shifting chest infiltrates in week 2. Twenty percent of patients progressed to ARDS during the third week of the illness. Quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate in 14 patients with relapse showed peak viral loads occurred at day 10 after onset of symptoms, suggesting that the late deterioration may be due to the host immune response rather than to uncontrolled viral replication.
(Granted, the Japanese woman's symptoms disappeared for almost a month before reappearing.)
https://www.mayoclinicproceedings.org/article/S0025-6196(11)...
It's called a cytokine storm.
This is why this virus is not only dangerous to the old and weak, a healthy person's immune system becomes a liability in the following phases of infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711683/
Confirmed Cases (%) | Deaths (%) | CFR
Overall | 44,672 | 1,023| 2.3
Age, years
0–9 | 416 | (0.9) | − −
10–19 | 549 (1.2) | 1 (0.1) | 0.2
20–29 | 3,619 (8.1) | 7 (0.7) | 0.2
30–39 | 7,600 (17.0) | 18 (1.8) | 0.2
40–49 | 8,571 (19.2) | 38 (3.7) | 0.4
50–59 | 10,008 (22.4) | 130 (12.7) | 1.3
60–69 | 8,583 (19.2) | 309 (30.2) | 3.6
70–79 | 3,918 (8.8) | 312 (30.5) | 8.0
≥80 | 1,408 (3.2) | 208 (20.3) | 14.8
Sex
Male | 22,981 (51.4) | 653 (63.8) | 2.8
Female | 21,691 (48.6) | 370 (36.2) | 1.7
Occupation
Service industry | 3,449 (7.7) | 23 (2.2) | 0.7
Farmer/laborer | 9,811 (22.0) | 139 (13.6) | 1.4
Health worker | 1,716 (3.8) | 5 (0.5) | 0.3
Retiree | 9,193 (20.6) | 472 (46.1) | 5.1
Other/none | 20,503 (45.9) | 384 (37.5) | 1.9
Province
Hubei | 33,367 (74.7) | 979 (95.7) | 2.9
Other | 11,305 (25.3) | 44 (4.3) | 0.4
Wuhan-related exposure*
Yes | 31,974 (85.8) | 853 (92.8) | 2.7
No | 5,295 (14.2) | 66 (7.2) | 1.2
Missing | 7,403 | 104 | 2.8
Comorbid condition †
Hypertension | 2,683 (12.8) | 161 (39.7) | 6.0
Diabetes | 1,102 (5.3) | 80 (19.7) | 7.3
Cardiovascular disease | 873 (4.2) | 92 (22.7) | 10.5
Chronic respiratory disease | 511 (2.4) | 32 (7.9) | 6.3
Cancer (any) | 107 (0.5) | 6 (1.5) | 5.6
None | 15,536 (74.0) | 133 (32.8) | 0.9
Missing | 23,690 (53.0) | 617 (60.3) | 2.6
Case severity §
Mild | 36,160 (80.9) − − − −
Severe | 6,168 (13.8) − − − −
Critical | 2,087 (4.7) | 1,023 (100) | 49.0
Missing | 257 (0.6) − − − −
[0] https://drive.google.com/file/d/1CbsG_zfvOmTWK8rCzr7XM2vSfSV...1. This was a tour bus guide. Someone who had almost certainly come into contact with people from different countries.
2. She's not the first patient to relapse.
In my personal opinion living and working here, this society is very slow to change and things that could greatly assist in slowing the spread, such as adopting a Work From Home policy, will only occur once it's too late. Almost no one is allowed to work from home here, even those with office/tech jobs that can completely be done remotely with no issues. In addition, workers are granted an incredibly small amount of days off, and most would rather get onto their very crowded trains and commute into the office even when unwell as opposed to taking one of their limited days off.
All that being said I'm not freaking out about it the way most people here are, but I wish companies would react a bit faster and change their work culture to accommodate the very easy things that could be done so people can limit their interactions with others when something like this is occurring. You can pretty much guarantee that one person with the virus getting onto a sardine can train during their morning commute is going to infect several other people in the process, and no amount of face masks the people here are so fond of will do anything to keep an infection at bay.
Well that's the company I'm employed by, but the company I'm currently deployed at (until today) is an automotive company and they don't seem ready to allow much remote work to take place.
IT as in Information Technology or Italy?
Edit: lots of downvotes but that was a serious question.
I've seen the panic mentality here in Hong Kong, and there's no real difference between the people who panicked, and the people who didn't. Panicking just makes it worse for everyone else.
If it is actually serious enough to avoid going near foreigners, why is international travel being allowed at all?
At 3000+, we are already inching towards 5 digits with one more city : area going bad.
The best we can hope for is to reduce exposure, slow down progression, and thus spread the development over months.
This will allow the medical services to treat the 20% critical cases, without getting overwhelmed.
The NHK said that this woman had no contact with anyone after being released. I believe that, being one of the first cases, someone botched up the testing or she was discharged too early.
Normally if you get sick, and it develops into bronchitis, the doctor just prescribes you some antibiotics, the ZPack. Has that not helped in this situation?
One possible positive if there is such a thing is that if "Wuhan Fever" becomes a pandemic that kills off a large enough portion of the global population maybe it will solve the global warming crisis or at the least slow it down.
The global warming crisis is a crisis because it has the potential to kill off a large portion of the global population. I'm not an expert or anything but a pandemic that does the same thing doesn't seem like an improvement.
I would also imagine that there may be a reduction in holiday travel plans just out of fear of being quarantined.
Not to mention the effect a global recession would have on CO2 production.
Perhaps we can have a way to reduce global climate change without mass suffering and death.
I think it’s morally cheap of people to talk about the seriousness of global warming and the necessity of solving it without thinking far out about what sort of world they’re imagining. There must be global one child policies. They must be enforced strongly. Consumption must be limited. And it’s all dependent on the idea that all governments are unified enough to enforce policies against their people that run against basic human desires, while also holding every other government accountable for enacting similar policies, and none is corrupt enough to break the rules.
I agree that global warming is real. I agree that it’s an incredible danger to humanity. But when you consider the type of world necessary to actually follow through with fixing global warming, you come to the conclusion that it’s a world that’s best ruled by a totalitarian global government where the norm is that most are robbed of basic human experiences like eating well and having children. Is that even a world worth saving?
So to those responding that this parent comment is in bad taste, I agree, but I am someone who is doesn’t believe in trying stopping global warming to begin with, so I’m allowed to not see a silver lining in mass death. Are you? If you’re not okay with my parent comments reasoning but you do believe that global warming must be stopped, I have to wonder what you think solving global warming is going to be like in a few hundred years, and if you’re prepared for the moral hazards much worse than this.
That being said, considering the solutions to over population of the earth that you listed, a pandemic almost seems like a righteous act of God that would be accepted by all nations.