Try 10%.
"Studies suggest that approximately 10% of the world population is left-handed. [...] Studies suggest that approximately 90% of the world population is right-handed." [1]
The same webpage also suggests that in e.g. sports, left handed people are overrepresented and have an [at times severe] advantage.
There are approximately 2% of people in wheel-chairs in the UK and approximately 3% of blind people, would you ignore them in your accessibility design? No, of course not. Then why should 10% of left-handers be ignored?
And before you say 'left-handedness is not a disability' try living as a leftie for 1 week, and see the problems we have to deal with every day.
No, I'm sorry you got that impression. I am just setting the facts straight (20% is a completely different percentage than 10%). My partner is left-handed, my daughter might be, and I grew up with a disabled father (he ended up in wheelchair and was practically blind). I feel a lot of empathy to minority groups such as the ones you mentioned (plus a myriad of others).
In my youth, I knew a guy who'd cross his arms while gaming (he was left-handed). This was approx 1995. Quite clever. He was using the mouse with his left hand, and the keyboard with his right. It worked for him (he was a decent gamer). He adopted, though it looked weird.
Ok, Fair enough :)