If there are efficiency gains to be had from using jumbo frames, wouldn't setting my MTU to a multiple a 1500 still be of some benefit? If my PC, my switch and my router all support it, that would still be a tiiiny improvement. If the server's network does as well and let's say both of our direct providers, even if none of the exchanges or backbones in between do, that would still be an efficiency gain for ~10% of the link, right?